Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 5/20 | 1.00 |
| ▸ | MAX | P61244 | 4/20 | 1.00 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 6/20 | 0.51 |
| ▸ | MAOB | P27338 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20816069 | 1.00 | MYC (1.00) | MYCMAXAMY1AMEN1NPC1 | |
| SCHEMBL25645369 | 0.81 | MYC (0.68) | MYCMAXMEN1NPC1RAB9A | |
| SCHEMBL17927320 | 0.80 | MAPK1 (0.71) | MYCMAXKMT2AMAPK1MAOA | |
| SCHEMBL17927322 | 0.80 | MAPK1 (0.71) | MYCMAXKMT2AMAPK1MAOA | |
| SCHEMBL17934519 | 0.77 | MYC (0.63) | MYCMAXMEN1NPC1RAB9A | |
| SCHEMBL17927318 | 0.75 | MYC (0.60) | MYCMAXMEN1ALDH1A1KMT2A | |
| SCHEMBL17927286 | 0.75 | MYC (0.60) | MYCMAXNPC1MAPK1MAOA | |
| SCHEMBL17927319 | 0.75 | MYC (0.60) | MYCMAXMEN1ALDH1A1KMT2A | |
| SCHEMBL31376923 | 0.75 | MYC (0.68) | MYCMAXMEN1NPC1ALDH1A1 | |
| SCHEMBL31376941 | 0.75 | AKR1B1 (0.76) | MYCMAXKDRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190085404-A1 | METHODS OF IDENTIFYING AND TREATING IMMUNE CHECKPOINT INHIBITOR-RESPONSIVE NEOPLASMS AND CELLS, TRANSGENIC ANIMALS AND KITS FOR USE THEREIN | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2019-03-21 | — | — | US | disclosed |