Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Enalapril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 14/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.91 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enalapril SCHEMBL10 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL2719411 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL9 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL6155137 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL10390115 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL1650291 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL308603 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL825430 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL9019924 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| Enalapril SCHEMBL9019927 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2ACELMNAABCB11MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105125514-A | Stable enalapril maleate capsules and preparation method thereof | CSPC PHARMACEUTICAL GROUP OUYI PHARMA CO LTD | 2015-12-09 | — | — | CN | claimed |
| CN-104055730-A | Enalapril maleate oral solution and preparation method thereof | AVENTIS PHARMA HAINAN CO LTD | 2014-09-24 | — | — | CN | claimed |
| CN-101721383-A | Enalapril maleate tablet and preparation method thereof | JIANGSU PENGYAO PHARMACEUTICAL | 2010-06-09 | — | — | CN | claimed |
| CN-101269042-A | Enalapril maleate sustained-release dropping pill and preparation method thereof | CHIA TAI GREEN CONTINENT PHARM (CN) | 2008-09-24 | — | — | CN | claimed |
| CN-117205165-A | Prescription process development of enalapril maleate tablets for pets | 安徽爱宠生物科技有限公司 | 2023-12-12 | — | — | CN | disclosed |
| WO-2022124243-A1 | TIMED-ELUTION MASKING PARTICLES AND ORAL PHARMACEUTICAL COMPOSITION CONTAINING SAME | 東和薬品株式会社 | 2022-06-16 | — | — | WO | disclosed |
| CN-110117309-A | Isomer impurities and its synthetic method in a kind of enalapril maleate bulk pharmaceutical chemicals | 常州制药厂有限公司 | 2019-08-13 | — | — | CN | disclosed |
| WO-2019055859-A1 | TREATMENT OF METABOLIC SYNDROME WITH AN SGC STIMULATOR | IRONWOOD PHARMACEUTICALS, INC. (US) | 2019-03-21 | — | — | WO | disclosed |
| CN-105125514-A | Stable enalapril maleate capsules and preparation method thereof | CSPC PHARMACEUTICAL GROUP OUYI PHARMA CO LTD | 2015-12-09 | — | — | CN | disclosed |
| CN-101721383-B | Enalapril maleate tablet and preparation method thereof | JIANGSU PENGYAO PHARMACEUTICALS INC | 2012-11-07 | — | — | CN | disclosed |
| CN-101836982-A | Medicinal composition for curing hypertension | BEIJING DVENTUREPHARM TECHNOLOGY DEV CO LTD | 2010-09-22 | — | — | CN | disclosed |
| CN-101721383-A | Enalapril maleate tablet and preparation method thereof | JIANGSU PENGYAO PHARMACEUTICAL | 2010-06-09 | — | — | CN | disclosed |
| CN-1320885-C | Enapoli maleate dispersion tablet and its preparation technology | QIAN CHUNTAO (CN) | 2007-06-13 | — | — | CN | disclosed |
| CN-1269529-C | Medicinal composition contaniing angiotensin invertase inhibitor and vitamin B | ANHUI BIOMEDICAL INST (CN) | 2006-08-16 | — | — | CN | disclosed |
| CN-1650859-A | Enapoli maleate dispersion tablet and its preparation technology | QIAN CHUNTAO (CN) | 2005-08-10 | — | — | CN | disclosed |
| CN-1587270-A | Medicinal composition contaniing angiotensin invertase inhibitor and vitamin B | ANHUI PROV BIOLOG MEDICINE I (CN) | 2005-03-02 | — | — | CN | disclosed |
| CN-1429835-A | Preparation method of N-carboxyalkyl dipeptide type angiotensin converting enzyme inhibitor | SHANGHAI MEDICINE INDUSTRY INS (CN) | 2003-07-16 | — | — | CN | disclosed |