Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.66 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.66 |
| ▸ | SLC9A5 | Q14940 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | TSHR | P16473 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | GLA | P06280 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.66 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2690754 | 0.85 | PLAU (0.83) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| Amiloride SCHEMBL27563 | 0.79 | PLAU (1.00) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| Amiloride SCHEMBL29531132 | 0.79 | PLAU (1.00) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| Amiloride SCHEMBL4155066 | 0.78 | ALDH1A1 (1.00) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| SCHEMBL6017198 | 0.77 | PDPK1 (0.45) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| Amiloride SCHEMBL136682 | 0.77 | PLAU (0.93) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| Amiloride SCHEMBL871514 | 0.75 | PLAU (0.90) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| SCHEMBL10087514 | 0.75 | PLAU (0.73) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| SCHEMBL19341331 | 0.73 | PLAU (0.69) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 | |
| SCHEMBL2850325 | 0.73 | TDP1 (0.52) | PLAUSLC9A1CYP1A2SLC9A5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190083527-A1 | METHOD OF ADMINISTRATION AND TREATMENT | Ampersand Biopharmaceuticals, Inc. (US) | 2019-03-21 | — | — | US | disclosed |