Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 4/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2082268 | 1.00 | CYP3A4 (0.47) | CYP3A4CSNK2A2CSNK2BCSNK2A1CHRM1 | |
| SCHEMBL9147990 | 0.89 | CYP3A4 (0.48) | CYP3A4CHRM1ALDH1A1POLBCHRM2 | |
| SCHEMBL9147833 | 0.89 | CYP3A4 (0.48) | CYP3A4CHRM1ALDH1A1POLBCHRM2 | |
| SCHEMBL9147828 | 0.89 | CYP3A4 (0.48) | CYP3A4CHRM1ALDH1A1POLBCHRM2 | |
| SCHEMBL4747726 | 0.88 | CYP3A4 (0.48) | CYP3A4CSNK2A2CSNK2BCSNK2A1CHRM1 | |
| SCHEMBL2079699 | 0.83 | TDP1 (0.44) | CYP3A4ALDH1A1POLB | |
| SCHEMBL2079698 | 0.83 | TDP1 (0.44) | CYP3A4ALDH1A1POLB | |
| SCHEMBL23298393 | 0.81 | CYP3A4 (0.56) | CYP3A4CHRM1ALDH1A1POLBCHRM2 | |
| SCHEMBL9146693 | 0.81 | CYP3A4 (0.48) | CYP3A4CHRM1ALDH1A1POLBCHRM2 | |
| SCHEMBL9146697 | 0.81 | CYP3A4 (0.48) | CYP3A4CHRM1ALDH1A1POLBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902226-B2 | Dehalogeno-compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-03-08 | — | — | US | disclosed |
| EP-1336611-B1 | DEHALOGENO COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2007-09-05 | — | — | EP | disclosed |
| US-20070123560-A1 | Dehalogeno-compounds | DAIICHI PHARMACEUTICAL CO., LTD. | 2007-05-31 | — | — | US | disclosed |
| US-20040063754-A1 | Dehalogeno compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-01 | — | — | US | disclosed |
| EP-1336611-A1 | DEHALOGENO COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063754-A1 | Dehalogeno compounds | DEK, PGLS, RPS27L | CYP3A4 198/4885CSNK2A2 2804/4885CSNK2B 2244/4885 |
| US-20070123560-A1 | Dehalogeno-compounds | DEK, RPS27L, POLL | CYP3A4 277/4885CSNK2A2 2387/4885CSNK2B 1608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.