PGLS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to PGLS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
24-Week Study to Assess the PD, Safety, Tolerability, and PK of GLM101 in Participants With PMM2-CDG	PHASE2	COMPLETED
Open-Label Extension Study to Assess GLM101 in PMM2-CDG Patients	PHASE2	ENROLLING_BY_INVITATION
Efficacy Study of Daily Administration of VPA in Patients Affected by Wolfram Syndrome	PHASE2	UNKNOWN
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Vaccine Treatment for Advanced Non-Small Cell Lung Cancer	PHASE1/PHASE2	COMPLETED
The Effects of GLA on Human Volunteers	PHASE1	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Diagnosis of Pheochromocytoma	PHASE1	RECRUITING
Phase 1 Clinical Trial to Evaluate the Effect of DWP14012 on the Pharmacokinetics of DWC202201 in Healthy Subjects	PHASE1	UNKNOWN
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)	nan	COMPLETED
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism	nan	NOT_YET_RECRUITING
Glycosylation in Patients With Galactosaemia	nan	COMPLETED
Efficacy of a Rinse Containing Sea Salt and Lysozyme on Biofilm and Gingival Health	nan	COMPLETED
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
Evaluation of Blood Protein O-GlcNAcylation Levels in Children	nan	RECRUITING
A Retrospective Study to Identify New Omics Biomarkers of Chronic/Persistent Low Back Pain	nan	COMPLETED
Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children	nan	RECRUITING
Effect of an Polyphenolic Beverage in Healthy Volunteers	nan	ACTIVE_NOT_RECRUITING
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease	nan	RECRUITING
GSD VI and GSD IX Natural History	nan	RECRUITING
Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study	nan	NOT_YET_RECRUITING
99Tc-MDP in Postmenopausal Women With Differentiated Thyroid Cancer and Osteoporosis	nan	COMPLETED
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
'Glycogen Storage Diseases (GSDs) in Indian Children- Establishing an Indian GSD (I-GSD) Registry'	nan	RECRUITING
Genetic Analysis of Gray Platelet Syndrome	nan	COMPLETED
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
IMPROV (Improving the Radical Cure of Vivax Malaria)	nan	COMPLETED
Studying Phosphorus Metabolism	nan	COMPLETED
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED
Post Marketing Registry to Assess Usage, Safety and Effectiveness of Deltyba Tablets in Korean Patients With MDR-TB	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PGLS binder may also engage these)

Protein	Name	Similarity
P85971	—	1.000	P85971 →
Q2TBQ8	—	0.998	Q2TBQ8 →
Q9CQ60	—	0.996	Q9CQ60 →
Q865R1	—	0.974	Q865R1 →
Q8R123	—	0.974	Q8R123 →
Q86U10	—	0.971	Q86U10 →
TARS2	Threonine--tRNA ligase, mitochondrial	0.969	landscape →
A0A1U8CC89	—	0.968	A0A1U8CC89 →
Q8C0L6	—	0.968	Q8C0L6 →
PAOX	Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0.968	landscape →
Q3SZ07	—	0.967	Q3SZ07 →
Q9HAB8	—	0.967	Q9HAB8 →
Q8IVS8	—	0.966	Q8IVS8 →
Q8VCZ9	—	0.966	Q8VCZ9 →
Q8CFX1	—	0.965	Q8CFX1 →
P56201	—	0.965	P56201 →
Q8WZ82	—	0.965	Q8WZ82 →
Q8K4F6	—	0.965	Q8K4F6 →
Q8BYR1	—	0.964	Q8BYR1 →
FLAD1	FAD synthase	0.964	landscape →
A0JNU3	—	0.964	A0JNU3 →
Q0VGK3	—	0.964	Q0VGK3 →
Q86Y79	—	0.964	Q86Y79 →
Q9D7E3	—	0.964	Q9D7E3 →
Q8BW00	—	0.963	Q8BW00 →
O95479	—	0.963	O95479 →
Q5XIA3	—	0.963	Q5XIA3 →
Q68FW7	—	0.963	Q68FW7 →
O43542	—	0.963	O43542 →
PNKP	Bifunctional polynucleotide phosphatase/kinase	0.963	landscape →