Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.75 |
| ▸ | CTRL | P40313 | 2/20 | 0.75 |
| ▸ | PSMB5 | P28074 | 14/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.74 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.74 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.74 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.74 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.74 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.74 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.74 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.74 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.74 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.74 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.74 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.74 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.74 |
| ▸ | CTSB | P07858 | 1/20 | 0.74 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.74 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851642 | 1.00 | TMPRSS11D (0.75) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL15634574 | 0.97 | TMPRSS11D (0.73) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL17452276 | 0.97 | TMPRSS11D (0.73) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL15634572 | 0.97 | TMPRSS11D (0.73) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL31192812 | 0.97 | TMPRSS11D (0.73) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL23616318 | 0.95 | CTRL (0.80) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL20825238 | 0.95 | CTRL (0.80) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL8075093 | 0.95 | CTRL (0.80) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL8080983 | 0.95 | CTRL (0.80) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL18257553 | 0.95 | CTRL (0.80) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364269-B2 | Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof | LAURUS LABS LIMITED (IN) | 2019-07-30 | — | — | US | disclosed |
| US-20190085026-A1 | AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | Laurus Labs Ltd. (IN) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190085026-A1 | AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | PRCP, SF3B5, GBA1 | TMPRSS11D 459/4885CTRL 7/4885PSMB5 28/4885 |
| US-10364269-B2 | Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof | SF3B5, PRCP, GBA1 | TMPRSS11D 513/4885CTRL 10/4885PSMB5 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.