Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 13/20 | 0.44 |
| ▸ | IDO1 | P14902 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18766880 | 0.89 | HRH4 (0.47) | HRH4HRH3IDH1IDO1 | |
| SCHEMBL18766989 | 0.85 | HRH4 (0.47) | HRH4HRH3IDH1IDO1 | |
| SCHEMBL17149866 | 0.78 | IDO1 (0.59) | HRH4HRH3IDO1 | |
| SCHEMBL18766930 | 0.72 | HRH4 (0.44) | HRH4HRH3IDH1 | |
| SCHEMBL17149909 | 0.72 | IDO1 (0.61) | HRH4HRH3IDO1 | |
| SCHEMBL18766922 | 0.71 | IDH1 (0.45) | HRH4HRH3IDH1 | |
| SCHEMBL18766993 | 0.67 | HRH4 (0.55) | HRH4HRH3 | |
| SCHEMBL17149870 | 0.67 | IDO1 (0.58) | HRH4IDO1 | |
| SCHEMBL18766996 | 0.67 | HRH4 (0.45) | HRH4HRH3IDH1IDO1 | |
| SCHEMBL5731862 | 0.65 | HRH4 (0.51) | HRH4HRH3IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858319-B2 | Indole derivatives for use in medicine | IOMET PHARMA LTD. (GB) | 2020-12-08 | — | — | US | disclosed |
| US-20190084933-A1 | INDOLE DERIVATIVES FOR USE IN MEDICINE | IOMET PHARMA LTD. (GB) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858319-B2 | Indole derivatives for use in medicine | IDO1, IDO2, TDO2 | HRH4 64/4885HRH3 111/4885IDH1 239/4885 |
| US-20190084933-A1 | INDOLE DERIVATIVES FOR USE IN MEDICINE | IDO1, IDO2, TDO2 | HRH4 72/4885HRH3 128/4885IDH1 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.