Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 4/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 3/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20811694 | 0.88 | PDE2A (0.36) | PDE2ATEAD1 | |
| SCHEMBL20811547 | 0.79 | MAOA (0.37) | PDE2ATEAD1KIF11CES2CES1 | |
| SCHEMBL20811548 | 0.79 | MAOA (0.37) | PDE2ATEAD1KIF11CES2CES1 | |
| Hydrochloric Acid SCHEMBL22206747 | 0.77 | MAOA (0.36) | PDE2ATEAD1KIF11CES2CES1 | |
| Hydrochloric Acid SCHEMBL22206746 | 0.77 | MAOA (0.36) | PDE2ATEAD1KIF11CES2CES1 | |
| SCHEMBL11869627 | 0.73 | PDE2A (0.34) | PDE2ATEAD1 | |
| SCHEMBL23211870 | 0.71 | DPP4 (0.46) | TEAD1AKR1C3AKR1C2CES2CES1 | |
| Formic Acid SCHEMBL21381688 | 0.71 | KCNH2 (0.41) | PDE2ATEAD1HSD11B1AKR1C3AKR1C2 | |
| SCHEMBL9227942 | 0.70 | PDE2A (0.38) | PDE2AKIF11 | |
| SCHEMBL23211932 | 0.70 | TEAD1 (0.40) | PDE2ATEAD1HSD11B1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019055590-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | AMGEN INC. (US) | 2019-03-21 | — | — | WO | disclosed |