Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 11/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15725186 | 1.00 | GLS (0.70) | GLSMAPTRECQLALDH1A1PKM | |
| SCHEMBL15725195 | 0.98 | GLS (0.70) | GLSMAPTRECQLALDH1A1PKM | |
| SCHEMBL15725187 | 0.93 | GLS (0.66) | GLSMAPTPKMSMN1; SMN2 | |
| SCHEMBL20828348 | 0.93 | GLS (0.66) | GLSMAPTPKMSMN1; SMN2 | |
| SCHEMBL15725188 | 0.93 | GLS (0.66) | GLSMAPTRECQLALDH1A1PKM | |
| SCHEMBL15725189 | 0.93 | GLS (0.66) | GLSMAPTRECQLALDH1A1PKM | |
| SCHEMBL17172644 | 0.92 | GLS (0.62) | GLSMAPTRECQLALDH1A1KDM4E | |
| SCHEMBL15752641 | 0.90 | GLS (0.67) | GLSMAPTRECQLALDH1A1PKM | |
| SCHEMBL20392401 | 0.89 | GLS (0.66) | GLSMAPTRECQLALDH1A1PKM | |
| SCHEMBL15725192 | 0.89 | GLS (0.66) | GLSMAPTRECQLALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3456719-A1 | COMPOUNDS AND THEIR METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2019-03-20 | — | — | EP | disclosed |