Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 11/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15725181 | 0.91 | GLS (0.63) | GLSSMN1; SMN2 | |
| SCHEMBL17172639 | 0.86 | GLS (0.57) | GLSRAB9A | |
| SCHEMBL17172548 | 0.86 | GLS (0.57) | GLSRAB9A | |
| SCHEMBL15725185 | 0.81 | GLS (0.67) | GLSMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15725182 | 0.80 | GLS (0.64) | GLSMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL20392328 | 0.80 | GLS (0.49) | GLSMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15725178 | 0.79 | GLS (0.65) | GLSMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15725177 | 0.79 | GLS (0.61) | GLSMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL17172664 | 0.78 | GLS (0.59) | GLSMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL15752627 | 0.78 | GLS (0.61) | GLSMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3456719-A1 | COMPOUNDS AND THEIR METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2019-03-20 | — | — | EP | disclosed |