Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 8/20 | 0.63 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | GUSB | P08236 | 1/20 | 0.57 |
| ▸ | CFTR | P13569 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20392305 | 0.99 | GLS (0.65) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15725086 | 0.96 | GLS (0.65) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15725085 | 0.96 | GLS (0.65) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15725114 | 0.94 | GLS (0.68) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15725011 | 0.94 | GLS (0.68) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15725147 | 0.91 | GLS (0.67) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15725041 | 0.91 | GLS (0.67) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15725077 | 0.91 | GLS (0.67) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15709926 | 0.90 | GLS (0.63) | GLSMEN1KMT2APOLBCYP2C19 | |
| SCHEMBL15725063 | 0.90 | GLS (0.63) | GLSMEN1KMT2APOLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3456719-A1 | COMPOUNDS AND THEIR METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2019-03-20 | — | — | EP | disclosed |