Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2082281 | 0.88 | SMYD3 (0.43) | SMYD3SLC16A3KDM4EALDH1A1POLB | |
| SCHEMBL7174701 | 0.83 | SMYD3 (0.40) | SMYD3POLBPDGFRBFGFR1KDR | |
| SCHEMBL6621623 | 0.82 | SMYD3 (0.42) | SMYD3SLC16A3KDM4EALDH1A1POLB | |
| SCHEMBL2082255 | 0.79 | TOP1 (0.47) | SMYD3SLC16A3KDM4EALDH1A1POLB | |
| SCHEMBL2082993 | 0.78 | KDM4E (0.37) | SMYD3SLC16A3KDM4EALDH1A1POLB | |
| SCHEMBL9288768 | 0.77 | SLC16A3 (0.41) | SMYD3SLC16A3KDM4EALDH1A1POLB | |
| SCHEMBL29980141 | 0.75 | SLC16A3 (0.48) | SLC16A3KDM4EALDH1A1POLBGAA | |
| SCHEMBL9735507 | 0.75 | IP6K1 (0.51) | SLC16A3KDM4EALDH1A1POLBGAA | |
| SCHEMBL13581828 | 0.75 | SMYD3 (0.34) | SMYD3SLC16A3KDM4EALDH1A1POLB | |
| SCHEMBL3628697 | 0.75 | PIM2 (0.36) | POLBMGLLNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902226-B2 | Dehalogeno-compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-03-08 | — | — | US | disclosed |
| EP-1336611-B1 | DEHALOGENO COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2007-09-05 | — | — | EP | disclosed |
| US-20070123560-A1 | Dehalogeno-compounds | DAIICHI PHARMACEUTICAL CO., LTD. | 2007-05-31 | — | — | US | disclosed |
| US-20040063754-A1 | Dehalogeno compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-01 | — | — | US | disclosed |
| EP-1336611-A1 | DEHALOGENO COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063754-A1 | Dehalogeno compounds | DEK, PGLS, RPS27L | SMYD3 4806/4885SLC16A3 1580/4885KDM4E 2484/4885 |
| US-20070123560-A1 | Dehalogeno-compounds | DEK, RPS27L, POLL | SMYD3 4763/4885SLC16A3 2043/4885KDM4E 2618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.