Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.38 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | UGCG | Q16739 | 2/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | LCT | P09848 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209346 | 0.90 | HSD11B1 (0.48) | HSD11B1KDM4EALDH1A1 | |
| SCHEMBL4517502 | 0.85 | HSD11B1 (0.62) | HSD11B1ALDH1A1CCR5CES2ROCK2 | |
| SCHEMBL3551332 | 0.85 | HSD11B1 (0.64) | HSD11B1KDM4EALDH1A1CYP27A1CYP24A1 | |
| SCHEMBL3554331 | 0.84 | HSD11B1 (0.60) | HSD11B1CCR5CNR1CES2ROCK2 | |
| SCHEMBL208293 | 0.84 | HSD11B1 (0.43) | HSD11B1ALDH1A1 | |
| SCHEMBL209282 | 0.83 | HSD11B1 (0.52) | HSD11B1KDM4EALDH1A1CYP27A1CYP24A1 | |
| SCHEMBL208962 | 0.82 | KCNH2 (0.42) | HSD11B1 | |
| SCHEMBL207094 | 0.82 | HSD11B1 (0.41) | HSD11B1 | |
| SCHEMBL209678 | 0.82 | HDAC4 (0.42) | HSD11B1 | |
| SCHEMBL2723744 | 0.81 | HSD11B1 (0.40) | HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088776-B2 | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-01-03 | — | — | US | disclosed |