Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 4/20 | 0.66 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20831241 | 0.89 | TRPC5 (0.62) | TRPC5P2RX7PARP1KCNH2ALDH1A1 | |
| SCHEMBL25686925 | 0.88 | TRPC5 (0.61) | TRPC5P2RX7PARP1KCNH2ALDH1A1 | |
| SCHEMBL20831657 | 0.85 | TRPC5 (0.58) | TRPC5P2RX7ALDH1A1GAAMAPK1 | |
| SCHEMBL20831238 | 0.83 | TRPC5 (0.54) | TRPC5P2RX7PARP1KCNH2ALDH1A1 | |
| SCHEMBL20831243 | 0.83 | TRPC5 (0.56) | TRPC5P2RX7ALDH1A1MAPK1NPSR1 | |
| SCHEMBL20831664 | 0.83 | TRPC5 (0.57) | TRPC5P2RX7PARP1ALDH1A1GAA | |
| SCHEMBL20818676 | 0.81 | TRPC5 (0.60) | TRPC5P2RX7ALDH1A1GAAPOLB | |
| SCHEMBL20818295 | 0.80 | TRPC5 (0.59) | TRPC5P2RX7ALDH1A1GAAMAPK1 | |
| SCHEMBL20831808 | 0.80 | TRPC5 (0.65) | TRPC5P2RX7PARP1KCNH2ALDH1A1 | |
| SCHEMBL20818635 | 0.79 | TRPC5 (1.00) | TRPC5P2RX7ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019055966-A2 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-03-21 | — | — | WO | disclosed |