Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 5/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20832171 | 0.86 | TRPC5 (0.59) | TRPC5KDM4EKMT2AKAT2B | |
| SCHEMBL20831652 | 0.84 | TRPC5 (0.59) | TRPC5KDM4EALDH1A1ATMNPSR1 | |
| SCHEMBL20831508 | 0.73 | TRPC5 (0.57) | TRPC5KDM4EALDH1A1ATMNPSR1 | |
| SCHEMBL20831959 | 0.70 | TRPC5 (0.42) | TRPC5P2RX7KCNH2TRPC4C5AR1 | |
| SCHEMBL20831647 | 0.69 | TRPC5 (0.78) | TRPC5ALDH1A1KCNH2TRPC4 | |
| SCHEMBL20831958 | 0.69 | TRPC5 (0.68) | TRPC5KCNH2TRPC4 | |
| SCHEMBL20831554 | 0.69 | TRPC5 (0.68) | TRPC5KCNH2TRPC4 | |
| SCHEMBL20831957 | 0.69 | TRPC5 (0.68) | TRPC5KCNH2TRPC4 | |
| SCHEMBL25699755 | 0.68 | TRPC5 (0.35) | TRPC5KAT2BMAPT | |
| SCHEMBL20831868 | 0.67 | TRPC5 (0.60) | TRPC5ALDH1A1POLBKCNH2TRPC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019055966-A2 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-03-21 | — | — | WO | disclosed |