Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.51 |
| ▸ | CALCRL | Q16602 | 14/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28908005 | 0.90 | RIPK1 (0.51) | RIPK1CALCRLPDE5AMAOAMAOB | |
| SCHEMBL20835474 | 0.86 | CALCRL (0.50) | RIPK1CALCRLPDE5A | |
| SCHEMBL20835879 | 0.86 | RIPK1 (0.48) | RIPK1CALCRLPDE5A | |
| SCHEMBL20835925 | 0.86 | CALCRL (0.49) | RIPK1CALCRLPDE5A | |
| SCHEMBL20835539 | 0.86 | CALCRL (0.49) | RIPK1CALCRLPDE5AMAOAMAOB | |
| SCHEMBL20835532 | 0.86 | RIPK1 (0.48) | RIPK1CALCRLPDE5A | |
| SCHEMBL28521349 | 0.85 | RIPK1 (0.50) | RIPK1CALCRLPDE5AMAOAMAOB | |
| SCHEMBL20835601 | 0.85 | CALCRL (0.50) | RIPK1CALCRLPDE5A | |
| SCHEMBL20835868 | 0.84 | RIPK1 (0.46) | RIPK1CALCRLPDE5A | |
| SCHEMBL20843517 | 0.84 | CALCRL (0.50) | RIPK1CALCRLPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10995084-B2 | Pyrrolidine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2021-05-04 | — | — | US | disclosed |
| US-20200299273-A1 | PYRROLIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2020-09-24 | — | — | US | disclosed |
| EP-3459941-A1 | PYRROLIDINE DERIVATIVE | Kissei Pharmaceutical Co., Ltd. (JP) | 2019-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299273-A1 | PYRROLIDINE DERIVATIVE | CALCRL, NPY1R, GRPR | RIPK1 1917/4885CALCRL 1/4885PDE5A 439/4885 |
| US-10995084-B2 | Pyrrolidine derivative | CALCRL, NPY1R, GRPR | RIPK1 1917/4885CALCRL 1/4885PDE5A 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.