Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13470911 | 1.00 | ALOX5 (0.52) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL30364885 | 0.98 | ALOX5 (0.51) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14865093 | 0.93 | ALOX5 (0.50) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL28521923 | 0.91 | ALOX5 (0.48) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL17511101 | 0.90 | ALOX5 (0.52) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL17511100 | 0.90 | ALOX5 (0.52) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL28954144 | 0.88 | ALOX5 (0.47) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL17079002 | 0.85 | ALOX5 (0.49) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2775430 | 0.84 | HTT (0.58) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL19320482 | 0.84 | ALOX5 (0.53) | ALOX5PTGS2SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10995084-B2 | Pyrrolidine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2021-05-04 | — | — | US | disclosed |
| US-20200299273-A1 | PYRROLIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2020-09-24 | — | — | US | disclosed |
| EP-3459941-A1 | PYRROLIDINE DERIVATIVE | Kissei Pharmaceutical Co., Ltd. (JP) | 2019-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299273-A1 | PYRROLIDINE DERIVATIVE | CALCRL, NPY1R, GRPR | ALOX5 2554/4885PTGS2 933/4885SMN1; SMN2 3488/4885 |
| US-10995084-B2 | Pyrrolidine derivative | CALCRL, NPY1R, GRPR | ALOX5 2554/4885PTGS2 933/4885SMN1; SMN2 3488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.