Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.36 |
| ▸ | PAK3 | O75914 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300746 | 0.76 | MAPT (0.44) | MAPTEPHX2CXCR3CA12CA1 | |
| SCHEMBL17977242 | 0.76 | LMNA (0.50) | MAPTEPHX2P2RX1 | |
| SCHEMBL19805294 | 0.76 | LMNA (0.36) | MAPTEPHX2CXCR3P2RX1EPHX1 | |
| SCHEMBL3887744 | 0.73 | MAPT (0.43) | MAPTP2RX1EPHX1 | |
| SCHEMBL21859180 | 0.70 | MAPT (0.57) | MAPTEPHX2CXCR3CA12CA1 | |
| SCHEMBL5950295 | 0.70 | EPHX2 (0.51) | MAPTEPHX2CXCR3CA12CA1 | |
| SCHEMBL23854453 | 0.70 | MAPT (0.50) | MAPTEPHX2CXCR3CA12CA1 | |
| SCHEMBL4302653 | 0.70 | MAPT (0.50) | MAPTEPHX2CXCR3CA12CA1 | |
| SCHEMBL4302656 | 0.70 | MAPT (0.50) | MAPTEPHX2CXCR3CA12CA1 | |
| SCHEMBL5598039 | 0.69 | EPHX2 (0.75) | MAPTEPHX2CXCR3EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256444-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF NEP INHIBITORS | NOVARTIS AG (CH) | 2019-03-27 | — | — | EP | disclosed |