Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.39 |
| ▸ | PLK1 | P53350 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | YES1 | P07947 | 2/20 | 0.33 |
| ▸ | LYN | P07948 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | ROS1 | P08922 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20995387 | 0.92 | FGFR1 (0.39) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL30745814 | 0.89 | FGFR1 (0.40) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836806 | 0.89 | FGFR1 (0.40) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836828 | 0.87 | FGFR1 (0.42) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL19633296 | 0.85 | FGFR1 (0.43) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL30745800 | 0.84 | FGFR1 (0.47) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836793 | 0.84 | FGFR1 (0.47) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836798 | 0.82 | FGFR1 (0.41) | FGFR1FGFR4FGFR3FGFR2EGFR | |
| SCHEMBL28586199 | 0.79 | FGFR1 (0.43) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836829 | 0.78 | FGFR1 (0.42) | FGFR1FGFR4FGFR3FGFR2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459952-A1 | PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE | Zhejiang Hisun Pharmaceutical Co., Ltd. (CN) | 2019-03-27 | — | — | EP | disclosed |