Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.40 |
| ▸ | PLK1 | P53350 | 6/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | INSR | P06213 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | YES1 | P07947 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | ROS1 | P08922 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20836806 | 1.00 | FGFR1 (0.40) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20995387 | 0.97 | FGFR1 (0.39) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL28586199 | 0.89 | FGFR1 (0.43) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836827 | 0.89 | FGFR1 (0.39) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL19633409 | 0.88 | FGFR1 (0.42) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836791 | 0.87 | FGFR1 (0.48) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836798 | 0.87 | FGFR1 (0.41) | FGFR1FGFR4FGFR3FGFR2JAK2 | |
| SCHEMBL20836829 | 0.86 | FGFR1 (0.42) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL19633355 | 0.84 | FGFR1 (0.42) | FGFR1FGFR4FGFR3FGFR2PLK1 | |
| SCHEMBL20836824 | 0.83 | FGFR1 (0.55) | FGFR1FGFR4FGFR3FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12358898-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2025-07-15 | — | — | US | disclosed |
| US-20240018130-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2024-01-18 | — | — | US | disclosed |
| US-11827625-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. | 2023-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827625-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | FGFR4, FGFR1, FGFR2 | FGFR1 2/4885FGFR4 1/4885FGFR3 4/4885 |
| US-12358898-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | FGFR4, FGFR1, FGFR2 | FGFR1 2/4885FGFR4 1/4885FGFR3 4/4885 |
| US-20240018130-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | FGFR4, FGFR1, FGFR2 | FGFR1 2/4885FGFR4 1/4885FGFR3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.