⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13748413 | 0.78 | NR2F2 (0.36) | — | |
| SCHEMBL3714787 | 0.72 | GAA (0.33) | — | |
| SCHEMBL21754275 | 0.70 | BRD4 (0.36) | — | |
| SCHEMBL31078199 | 0.70 | — | — | |
| SCHEMBL16403745 | 0.67 | — | — | |
| SCHEMBL20142124 | 0.64 | PRKACA (0.43) | — | |
| SCHEMBL13162566 | 0.64 | IKBKB (0.41) | — | |
| SCHEMBL20931266 | 0.63 | IDO1 (0.31) | — | |
| SCHEMBL4625124 | 0.63 | HSD17B10 (0.35) | — | |
| SCHEMBL17730533 | 0.62 | TSHR (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738056-B2 | Pyrazolopyrimidinone compounds and uses thereof | ADURO BIOTECH INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190119285-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | CHINOOK THERAPEUTICS, INC. | 2019-04-25 | — | — | US | disclosed |
| WO-2019055750-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | Aduro Biotech, Inc. (US) | 2019-03-21 | — | — | WO | disclosed |