Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20838511 | 0.83 | PTPN5 (0.49) | PTPN5CYP1A2CYP2C9CYP2C19SLC40A1 | |
| SCHEMBL20838479 | 0.80 | CCR1 (0.42) | FGFR4ALDH1A1CCR1DYRK1AADORA3 | |
| SCHEMBL28004161 | 0.75 | CCR1 (0.50) | FGFR4MAPKAPK2SLC40A1ALDH1A1CCR1 | |
| SCHEMBL20838475 | 0.74 | MOK (0.39) | PTPN5CYP1A2CYP2C9CYP2C19SLC40A1 | |
| SCHEMBL3333964 | 0.74 | CCR1 (0.47) | FGFR4MAPKAPK2ALDH1A1CCR1MEN1 | |
| SCHEMBL20838495 | 0.71 | CCR1 (0.44) | FGFR4MAPKAPK2CYP2C19SLC40A1ALDH1A1 | |
| SCHEMBL21214237 | 0.71 | MAPT (0.48) | PTPN5CYP1A2CYP2C9CYP2C19SLC40A1 | |
| SCHEMBL6937489 | 0.71 | CYP1A2 (0.56) | PTPN5CYP1A2CYP2C9CYP2C19SLC40A1 | |
| SCHEMBL20882035 | 0.70 | CYP17A1 (0.38) | FGFR4MAPKAPK2CCR1DYRK1ARXFP1 | |
| SCHEMBL30711791 | 0.70 | CYP17A1 (0.38) | FGFR4MAPKAPK2CCR1DYRK1ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466931-B1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | UNIV GUANGDONG TECHNOLOGY (CN) | 2024-01-10 | — | — | EP | disclosed |
| US-10807957-B2 | Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease | UNIV GUANGDONG TECHNOLOGY (CN) | 2020-10-20 | — | — | US | disclosed |
| US-10807957-B2 | Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease | UNIV GUANGDONG TECHNOLOGY (CN) | 2020-10-20 | — | — | US | disclosed |
| EP-3466931-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | Guangdong University Of Technology (CN) | 2019-04-10 | — | — | EP | disclosed |
| EP-3466931-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | Guangdong University Of Technology (CN) | 2019-04-10 | — | — | EP | disclosed |
| US-20190092730-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | GUANGDONG UNIVERSITY OF TECHNOLOGY | 2019-03-28 | — | — | US | disclosed |
| US-20190092730-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | GUANGDONG UNIVERSITY OF TECHNOLOGY | 2019-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807957-B2 | Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease | SOD1, SLC30A6, SLC30A7 | PTPN5 4083/4885FGFR4 4150/4885MAPKAPK2 4191/4885 |
| US-20190092730-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | SOD1, SLC30A6, SLC30A7 | PTPN5 4083/4885FGFR4 4150/4885MAPKAPK2 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.