Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.58 |
| ▸ | KDM4A | O75164 | 1/20 | 0.58 |
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.37 |
| ▸ | KDM5A | P29375 | 5/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20838566 | 0.92 | KDM4C (0.46) | KDM4CKDM4AKDM5BKDM5ALMNA | |
| SCHEMBL20838561 | 0.79 | KDM5B (0.41) | KDM4CKDM4AKDM5BKDM5ALMNA | |
| SCHEMBL20838562 | 0.78 | KDM5A (0.51) | KDM4CKDM4AKDM5BKDM5ALMNA | |
| SCHEMBL20838560 | 0.77 | KDM5B (0.54) | KDM4CKDM4AKDM5BKDM5ALMNA | |
| SCHEMBL20838565 | 0.75 | KDM5A (0.54) | KDM4CKDM4AKDM5BKDM5ALMNA | |
| SCHEMBL20838568 | 0.73 | KDM5A (0.49) | KDM4CKDM5BKDM5ALMNA | |
| SCHEMBL16149577 | 0.67 | KDM5B (0.47) | KDM4CKDM4AKDM5BKDM5ALMNA | |
| SCHEMBL16150955 | 0.66 | KDM4C (0.77) | KDM4CKDM4AKDM5BKDM5A | |
| SCHEMBL16150767 | 0.64 | KDM4C (0.84) | KDM4CKDM4AKDM5BKDM5A | |
| SCHEMBL20125458 | 0.64 | KDM4C (0.84) | KDM4CKDM4AKDM5BKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190092771-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2019-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190092771-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, KDM5A | KDM4C 12/4885KDM4A 11/4885KDM5B 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.