Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 20/20 | 0.78 |
| ▸ | ATR | Q13535 | 5/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 9/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20843825 | 0.95 | ATM (0.79) | ATMATRKCNH2MTORPIK3CA | |
| SCHEMBL20839554 | 0.95 | ATM (0.79) | ATMATRKCNH2MTORPIK3CA | |
| SCHEMBL20839523 | 0.91 | ATM (0.77) | ATMATRKCNH2MTORPIK3CA | |
| SCHEMBL30189177 | 0.89 | ATM (0.68) | ATMATRKCNH2MTORPIK3CA | |
| SCHEMBL21911393 | 0.89 | ATM (0.68) | ATMATRKCNH2MTORPIK3CA | |
| SCHEMBL19584960 | 0.88 | ATM (1.00) | ATMATRKCNH2MTORPIK3CA | |
| SCHEMBL30972010 | 0.87 | ATM (0.60) | ATMATRKCNH2MTORPIK3CA | |
| SCHEMBL20839311 | 0.86 | ATM (0.61) | ATMATRMTORPIK3CA | |
| SCHEMBL30972080 | 0.86 | ATM (0.58) | ATMATRKCNH2MTORPIK3CA | |
| SCHEMBL30971906 | 0.86 | ATM (0.58) | ATMATRKCNH2MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111344293-A | 1, 3-dihydroimidazo [4, 5-c ] cinnolin-2-one compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2020-06-26 | — | — | CN | claimed |
| CN-116194109-A | Combination of antibody-drug conjugate and ATM inhibitor | 阿斯利康(英国)有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-111344293-A | 1, 3-dihydroimidazo [4, 5-c ] cinnolin-2-one compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2020-06-26 | — | — | CN | disclosed |
| WO-2019057757-A1 | 1,3-DIHYDROIMIDAZO[4,5-C]CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-03-28 | — | — | WO | disclosed |
| WO-2019057757-A1 | 1,3-DIHYDROIMIDAZO[4,5-C]CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-03-28 | — | — | WO | disclosed |