Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.70 |
| ▸ | PPARD | Q03181 | 4/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20839675 | 0.93 | NR1H4 (0.81) | NR1H4PPARDPPARGPPARANPC1 | |
| SCHEMBL20840618 | 0.91 | NR1H4 (0.59) | NR1H4PPARDPPARGPPARANPC1 | |
| SCHEMBL20839747 | 0.90 | NR1H4 (0.58) | NR1H4PPARDPPARGPPARANPC1 | |
| SCHEMBL20839666 | 0.89 | NR1H4 (0.86) | NR1H4PPARDPPARGPPARANPC1 | |
| SCHEMBL20839988 | 0.86 | NR1H4 (0.67) | NR1H4PPARDPPARGPPARANPC1 | |
| SCHEMBL20839936 | 0.84 | NR1H4 (0.65) | NR1H4PPARDPPARGPPARANPC1 | |
| SCHEMBL20839595 | 0.83 | NR1H4 (0.66) | NR1H4PPARDPPARGPPARANPC1 | |
| SCHEMBL20839731 | 0.83 | NR1H4 (0.80) | NR1H4PPARDPPARGPPARAMAPT | |
| SCHEMBL20839500 | 0.82 | NR1H4 (1.00) | NR1H4PPARDPPARGPPARANPC1 | |
| SCHEMBL20839944 | 0.81 | NR1H4 (0.49) | NR1H4PPARDNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057969-A1 | DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES | Johann Wolfgang Goethe-Universität (DE) | 2019-03-28 | — | — | WO | disclosed |