Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.70 |
| ▸ | PPARG | P37231 | 4/20 | 0.70 |
| ▸ | PPARD | Q03181 | 4/20 | 0.70 |
| ▸ | PPARA | Q07869 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20839940 | 0.87 | NR1H4 (0.59) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL20839638 | 0.85 | NR1H4 (0.73) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL20839783 | 0.81 | NR1H4 (0.80) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL344529 | 0.81 | MAPK1 (0.68) | NR1H4MAPK1PKMHTTMEN1 | |
| SCHEMBL7449026 | 0.81 | NR1H4 (0.72) | NR1H4PPARGPPARDPPARAMAPK1 | |
| SCHEMBL24133347 | 0.78 | NR1H4 (0.74) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL15528949 | 0.77 | RXFP1 (1.00) | RXFP1 | |
| SCHEMBL20839685 | 0.77 | RXFP1 (0.66) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL345796 | 0.76 | MAPK1 (0.58) | MAPK1PKMHTTMEN1KMT2A | |
| SCHEMBL5224986 | 0.75 | NR1H4 (0.73) | NR1H4PPARGPPARDPPARARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057969-A1 | DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES | Johann Wolfgang Goethe-Universität (DE) | 2019-03-28 | — | — | WO | disclosed |
| WO-2019057969-A1 | DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES | Johann Wolfgang Goethe-Universität (DE) | 2019-03-28 | — | — | WO | disclosed |