Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 15/20 | 0.73 |
| ▸ | PPARG | P37231 | 8/20 | 0.73 |
| ▸ | PPARD | Q03181 | 8/20 | 0.73 |
| ▸ | PPARA | Q07869 | 6/20 | 0.73 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20839941 | 0.85 | NR1H4 (0.70) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL20839783 | 0.83 | NR1H4 (0.80) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL24133347 | 0.82 | NR1H4 (0.74) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL20839685 | 0.81 | RXFP1 (0.66) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL15528949 | 0.79 | RXFP1 (1.00) | RXFP1 | |
| SCHEMBL15599961 | 0.78 | MEN1 (0.78) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL8044197 | 0.76 | DHODH (0.79) | NR1H4PPARGPPARDPPARAMEN1 | |
| SCHEMBL20839497 | 0.76 | RXFP1 (0.59) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL20839624 | 0.75 | NR1H4 (0.78) | NR1H4PPARGPPARDPPARARXFP1 | |
| SCHEMBL2467402 | 0.75 | PLAU (0.78) | NR1H4MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057969-A1 | DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES | Johann Wolfgang Goethe-Universität (DE) | 2019-03-28 | — | — | WO | disclosed |
| WO-2019057969-A1 | DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES | Johann Wolfgang Goethe-Universität (DE) | 2019-03-28 | — | — | WO | disclosed |