Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 16/20 | 0.93 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12935132 | 0.96 | CXCR4 (1.00) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5051496 | 0.96 | CXCR4 (1.00) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL23428698 | 0.89 | CXCR4 (0.78) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL12935122 | 0.84 | CXCR4 (1.00) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL22894622 | 0.84 | CXCR4 (0.71) | CXCR4KDM4EKCNA5KCNH2CYP2D6 | |
| SCHEMBL2084754 | 0.84 | CXCR4 (1.00) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL12935257 | 0.84 | CXCR4 (0.78) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5054913 | 0.83 | CXCR4 (1.00) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2084567 | 0.83 | CXCR4 (1.00) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL22894642 | 0.82 | CXCR4 (0.69) | CXCR4KDM4EKCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863293-B2 | CXCR4 chemokine receptor binding compounds | GENZYME CORPORATION (US) | 2011-01-04 | — | — | US | disclosed |
| US-20080255197-A1 | CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED CORPORATION (CA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255197-A1 | CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS | CXCR4, CXCR1, CXCR3 | CXCR4 1/4885CHRM2 655/4885CHRM4 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.