Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERO1A | Q96HE7 | 2/20 | 0.77 |
| ▸ | KDM1A | O60341 | 1/20 | 0.77 |
| ▸ | MAOA | P21397 | 1/20 | 0.77 |
| ▸ | MAOB | P27338 | 1/20 | 0.77 |
| ▸ | XPA | P23025 | 12/20 | 0.72 |
| ▸ | CTSB | P07858 | 1/20 | 0.69 |
| ▸ | EP300 | Q09472 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20840309 | 1.00 | ERO1A (0.77) | ERO1AKDM1AMAOAMAOBXPA | |
| SCHEMBL20848009 | 1.00 | ERO1A (0.77) | ERO1AKDM1AMAOAMAOBXPA | |
| SCHEMBL20840344 | 0.90 | XPA (0.73) | ERO1AKDM1AMAOAMAOBXPA | |
| SCHEMBL20840345 | 0.90 | XPA (0.73) | ERO1AKDM1AMAOAMAOBXPA | |
| SCHEMBL22219633 | 0.90 | XPA (0.73) | ERO1AKDM1AMAOAMAOBXPA | |
| SCHEMBL20840299 | 0.88 | XPA (0.81) | ERO1AKDM1AMAOAMAOBXPA | |
| SCHEMBL20848003 | 0.88 | XPA (0.81) | ERO1AKDM1AMAOAMAOBXPA | |
| SCHEMBL20840300 | 0.88 | XPA (0.81) | ERO1AKDM1AMAOAMAOBXPA | |
| SCHEMBL20840316 | 0.87 | EP300 (0.87) | XPAEP300KDM4EMEN1POLB | |
| SCHEMBL14426455 | 0.87 | EP300 (0.87) | XPAEP300KDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684354-B1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | UNIV INDIANA RES & TECH CORP (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11207296-B2 | XPA inhibitor compounds and their use | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2021-12-28 | — | — | US | disclosed |
| EP-3684354-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | Indiana University Research and Technology Corporation (US) | 2020-07-29 | — | — | EP | disclosed |
| US-20200222367-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-07-16 | — | — | US | disclosed |
| WO-2019060260-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2019-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200222367-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | XPOT, XPA, ERCC4 | ERO1A 926/4885KDM1A 2277/4885MAOA 3248/4885 |
| US-11207296-B2 | XPA inhibitor compounds and their use | XPOT, XPA, ERCC4 | ERO1A 926/4885KDM1A 2277/4885MAOA 3248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.