ERO1A — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5476639	0.58	3/20
SCHEMBL20840309	0.77	2/20
SCHEMBL20840310	0.77	2/20
SCHEMBL20848009	0.77	2/20
SCHEMBL20840344	0.68	2/20
SCHEMBL20840345	0.68	2/20
SCHEMBL22219633	0.68	2/20
SCHEMBL13479529	0.63	2/20
SCHEMBL20840299	0.61	2/20
SCHEMBL20840300	0.61	2/20
SCHEMBL20848003	0.61	2/20
SCHEMBL19654116	0.60	2/20
SCHEMBL20840293	0.60	2/20
SCHEMBL20840294	0.60	2/20
SCHEMBL20848005	0.60	2/20
SCHEMBL20840291	0.59	2/20
SCHEMBL20840292	0.59	2/20
SCHEMBL20848012	0.59	2/20
SCHEMBL5457416	0.58	2/20
SCHEMBL5457418	0.58	2/20

Clinical trials — most relevant to ERO1A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity	PHASE2	RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
EndoTAG-1 in Triple Receptor Negative Breast Cancer Patients	PHASE2	COMPLETED
The PROMISE Study: Duavee in Women With DCIS	PHASE2	COMPLETED
Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection	PHASE2	COMPLETED
Intraamniotic Administrations of ER004 to Male Subjects With X-linked Hypohidrotic Ectodermal Dysplasia	PHASE2	RECRUITING
A Study Evaluating Megestrol Acetate Modulation in Hormone Receptor Positive Advanced Breast Cancer	PHASE2	UNKNOWN
A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis	PHASE1	WITHDRAWN
Phase I Study of Novel Estrogen Receptor(ER) a36 Modifier Icaritin in Advanced Breast Cancer Patients	PHASE1	UNKNOWN
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People	EARLY_PHASE1	COMPLETED
Quantification of GADD34 Expression in RA	nan	COMPLETED
Effect of Protein on Endoplasmic Reticulum Stress	nan	NOT_YET_RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans	nan	UNKNOWN
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS	nan	RECRUITING
MEHMO Natural History and Biomarkers	nan	RECRUITING
Autophagy Bladder Cancer	nan	UNKNOWN
Study IL- 35 Level and Fibronectin Type Ⅲ Domain Containing Protein 5 \ Irsin (FNDC5 rs3480) Gene Variations in Chronic Hepatitis B.	nan	UNKNOWN
Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation?	nan	UNKNOWN
Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	nan	UNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Efficacy and Safety of Deep Cervical Lymph Node-vein Bypass Surgery in ALS Amyotrophic Lateral Sclerosis	nan	NOT_YET_RECRUITING
Tahini, Antioxidant Status and Endothelial Function	nan	COMPLETED
Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected By Hypohidrotic Ectodermal Dysplasia (ECP-012)	nan	COMPLETED
Study of Biomarkers in Tissue Samples From Patients With Breast Cancer	nan	UNKNOWN
sCD163 in ALS Patients	nan	COMPLETED
Effect of Tahini in Oxidative Stress and Endothelial Function in Diabetes	nan	COMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ERO1A binder may also engage these)

Protein	Name	Similarity
Q8R4A1	—	1.000	Q8R4A1 →
Q8R180	—	1.000	Q8R180 →
A5PJN2	—	1.000	A5PJN2 →
B6CVD7	—	1.000	B6CVD7 →
B1H1F9	—	0.984	B1H1F9 →
Q86YB8	—	0.984	Q86YB8 →
Q8R2E9	—	0.983	Q8R2E9 →
Q9C7S7	—	0.982	Q9C7S7 →
Q6DD71	—	0.982	Q6DD71 →
Q7T3D1	—	0.980	Q7T3D1 →
Q7X9I4	—	0.979	Q7X9I4 →
Q5RAP2	—	0.973	Q5RAP2 →
Q5R981	—	0.970	Q5R981 →
O70367	—	0.969	O70367 →
P03454	—	0.969	P03454 →
Q08834	—	0.969	Q08834 →
Q58DQ5	—	0.968	Q58DQ5 →
Q6YAT4	—	0.968	Q6YAT4 →
Q09328	—	0.968	Q09328 →
Q8C1F4	—	0.968	Q8C1F4 →
O70258	—	0.968	O70258 →
Q99LC3	—	0.968	Q99LC3 →
P12023	—	0.967	P12023 →
ABHD16A	Phosphatidylserine lipase ABHD16A	0.967	landscape →
P28039	—	0.967	P28039 →
O14525	—	0.967	O14525 →
Q8N6G5	—	0.967	Q8N6G5 →
Q4R6Y8	—	0.966	Q4R6Y8 →
Q5I598	—	0.966	Q5I598 →
Q5R2I8	—	0.966	Q5R2I8 →