Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20844708 | 0.83 | UCHL1 (0.41) | UCHL1USP30NOTUMGABRG2GABRB3 | |
| SCHEMBL21545305 | 0.81 | NOTUM (0.43) | UCHL1USP30NOTUMGABRG2GABRB3 | |
| SCHEMBL20840660 | 0.81 | UCHL1 (0.40) | UCHL1USP30NOTUMGABRG2GABRB3 | |
| SCHEMBL20840125 | 0.77 | NR1H2 (0.41) | UCHL1USP30GABRG2GABRB3GABRA5 | |
| SCHEMBL17113072 | 0.75 | UCHL1 (0.41) | UCHL1USP30NOTUMGABRG2GABRB3 | |
| SCHEMBL20839556 | 0.74 | UCHL1 (0.43) | UCHL1USP30NOTUMGABRG2GABRB3 | |
| SCHEMBL22689242 | 0.70 | UCHL1 (0.43) | UCHL1USP30NOTUMGABRG2GABRB3 | |
| SCHEMBL20874988 | 0.70 | AURKA (0.34) | UCHL1USP30GABRG2GABRB3GABRA5 | |
| SCHEMBL30071231 | 0.70 | AURKA (0.34) | UCHL1USP30GABRG2GABRB3GABRA5 | |
| SCHEMBL21438773 | 0.68 | NOTUM (0.47) | NOTUMLMNAPKMKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057946-A1 | MULTI-CYCLIC AROMATIC COMPOUNDS AS FACTOR D INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-03-28 | — | — | WO | disclosed |