SCHEMBL20846283

SCHEMBL20846283

COc1cccc2c1c(-c1cccc3ccccc13)c1ccccc1[n+]2C

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
ALDH1A1 P00352 1/20 0.45
RAB9A P51151 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
ACHE P22303 9/20 0.42
CNR2 P34972 1/20 0.38
STK10 O94804 1/20 0.38
SLK Q9H2G2 1/20 0.38
PPARG P37231 2/20 0.37
RXRA P19793 1/20 0.37
PPARD Q03181 1/20 0.37
PPARA Q07869 1/20 0.37
AHR P35869 1/20 0.37
BCHE P06276 2/20 0.36
MAOA P21397 1/20 0.35
TERT O14746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL20838943 0.99 MAPT (0.44) MAPTMEN1KMT2AALDH1A1RAB9A
SCHEMBL22320928 0.94 MAPT (0.47) MAPTMEN1KMT2AALDH1A1RAB9A
Bromide SCHEMBL30053306 0.93 MAPT (0.46) MAPTMEN1KMT2AALDH1A1RAB9A
Bromide SCHEMBL22320910 0.93 MAPT (0.46) MAPTMEN1KMT2AALDH1A1RAB9A
SCHEMBL20838949 0.83 ACHE (0.42) MAPTMEN1KMT2AALDH1A1RAB9A
Bromide SCHEMBL20840689 0.82 ACHE (0.44) MAPTMEN1KMT2AALDH1A1RAB9A
SCHEMBL20846049 0.81 ACHE (0.62) MAPTALDH1A1ACHEMAOA
Bromide SCHEMBL20838942 0.80 ACHE (0.60) MAPTALDH1A1ACHEMAOA
SCHEMBL7796061 0.77 MAPT (0.63) MAPTMEN1KMT2AALDH1A1RAB9A
Bromide SCHEMBL22320911 0.76 ACHE (0.41) MAPTMEN1KMT2ASMN1; SMN2ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11214687-B2 Small-molecule organic dyes UNIVERSITÄT BASEL (CH) 2022-01-04 US disclosed
US-20200255667-A1 SMALL-MOLECULE ORGANIC DYES UNIVERSITÄT BASEL (CH) 2020-08-13 US disclosed
WO-2019057451-A1 SMALL-MOLECULE ORGANIC DYES UNIVERSITÄT BASEL (CH) 2019-03-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11214687-B2 Small-molecule organic dyes SLC7A5, SLC30A5, ZKSCAN2 MAPT 3255/4885MEN1 2848/4885KMT2A 2515/4885
US-20200255667-A1 SMALL-MOLECULE ORGANIC DYES SLC7A5, SLC30A5, ZKSCAN2 MAPT 3255/4885MEN1 2848/4885KMT2A 2515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.