Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.51 |
| ▸ | GAA | P10253 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.51 |
| ▸ | GLA | P06280 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20847149 | 0.82 | HPGD (0.41) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL20847152 | 0.80 | HPGD (0.41) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL7058025 | 0.79 | HPGD (0.62) | ALDH1A1HPGDKMT2AHTTSMN1; SMN2 | |
| SCHEMBL5320024 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL150752 | 0.77 | NPC1 (0.44) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL5318300 | 0.77 | ALDH1A1 (0.52) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL23216255 | 0.76 | KMT2A (0.47) | ALDH1A1KDM4EGAAHPGDKMT2A | |
| SCHEMBL378049 | 0.75 | KMT2A (0.43) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL27418998 | 0.75 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL4915808 | 0.75 | KDM4E (0.53) | ALDH1A1KDM4EGAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11649251-B2 | Substituted inhibitors of menin-MLL and methods of use | KURA ONCOLOGY, INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-11649251-B2 | Substituted inhibitors of menin-MLL and methods of use | KURA ONCOLOGY, INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20200216471-A1 | SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHODS OF USE | KURA ONCOLOGY, INC. | 2020-07-09 | — | — | US | disclosed |
| WO-2019060365-A1 | SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHODS OF USE | KURA ONCOLOGY, INC. (US) | 2019-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11649251-B2 | Substituted inhibitors of menin-MLL and methods of use | MLLT1, MEN1, MLLT3 | ALDH1A1 4538/4885KDM4E 149/4885GAA 4292/4885 |
| US-20200216471-A1 | SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHODS OF USE | MLLT1, MEN1, MLLT3 | ALDH1A1 4538/4885KDM4E 149/4885GAA 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.