Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20849993 | 1.00 | CTNNB1 (0.46) | CTNNB1MMP9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL14962044 | 0.88 | CTNNB1 (0.47) | CTNNB1MMP9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL20363277 | 0.79 | CTNNB1 (0.51) | CTNNB1MMP9TDP1CTSSCTSK | |
| SCHEMBL1706739 | 0.77 | CTNNB1 (0.50) | CTNNB1MMP9CYP1A2TDP1CTSS | |
| SCHEMBL6446064 | 0.77 | CTNNB1 (0.50) | CTNNB1MMP9CYP1A2TDP1CTSS | |
| SCHEMBL1703307 | 0.77 | CTNNB1 (0.50) | CTNNB1MMP9CYP1A2TDP1CTSS | |
| SCHEMBL20849762 | 0.77 | MAPT (0.46) | CYP1A2POLBOPRM1OPRD1 | |
| SCHEMBL20849755 | 0.77 | MAPT (0.46) | CYP1A2POLBOPRM1OPRD1 | |
| SCHEMBL19230445 | 0.76 | CTNNB1 (0.51) | CTNNB1MMP9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL19230443 | 0.76 | CTNNB1 (0.51) | CTNNB1MMP9CYP2D6CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190092808-A1 | SYNTHESIS AND COMPOSITION OF RAPAFUCIN LIBRARIES | THE JOHNS HOPKINS UNIVERSITY | 2019-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190092808-A1 | SYNTHESIS AND COMPOSITION OF RAPAFUCIN LIBRARIES | MTOR, COASY, RICTOR | CTNNB1 4682/4885MMP9 4403/4885CYP2D6 1416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.