Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20840369 | 0.87 | DDB1 (0.52) | CRBNDDB1 | |
| SCHEMBL20840373 | 0.87 | CRBN (0.58) | CRBNDDB1IKZF3 | |
| SCHEMBL20850714 | 0.85 | DDB1 (0.63) | CRBNDDB1 | |
| SCHEMBL31729996 | 0.80 | DDB1 (0.58) | CRBNDDB1 | |
| SCHEMBL21071413 | 0.79 | CRBN (0.52) | CRBNDDB1 | |
| SCHEMBL21759498 | 0.78 | CRBN (0.67) | CRBNDDB1IKZF3 | |
| SCHEMBL21070571 | 0.78 | CRBN (0.53) | CRBNDDB1 | |
| SCHEMBL20845887 | 0.78 | CRBN (0.70) | CRBNDDB1IKZF3 | |
| SCHEMBL21759499 | 0.78 | CRBN (0.57) | CRBNDDB1IKZF3 | |
| SCHEMBL23908487 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019060742-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC (US) | 2019-03-28 | — | — | WO | disclosed |