Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB4 | Q15303 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.38 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15712607 | 0.93 | ERBB2 (0.48) | ERBB4EGFRMAOBERBB2PPARG | |
| SCHEMBL15712470 | 0.81 | ERBB4 (0.52) | ERBB4EGFRMAOBERBB2HSP90AA1 | |
| SCHEMBL15712887 | 0.80 | ERBB2 (0.52) | ERBB4EGFRMAOBERBB2PPARG | |
| SCHEMBL15712824 | 0.76 | EGFR (0.48) | ERBB4EGFRMAOBERBB2SYK | |
| SCHEMBL15712245 | 0.74 | ERBB4 (0.47) | ERBB4EGFRMAOBERBB2SYK | |
| SCHEMBL916112 | 0.74 | NAMPT (0.48) | ERBB4EGFRMAOBMAPTPTK2 | |
| SCHEMBL31735391 | 0.73 | BPTF (0.53) | ERBB4EGFRMAOB | |
| SCHEMBL15712265 | 0.71 | ERBB4 (0.55) | ERBB4EGFRMAOBERBB2SYK | |
| SCHEMBL7807789 | 0.71 | HDAC6 (0.52) | ERBB4EGFRHSP90AA1HSP90B1 | |
| SCHEMBL15712246 | 0.70 | NTSR1 (0.47) | ERBB4EGFRMAOBERBB2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2915804-B1 | NOVEL AMINE DERIVATIVE OR SALT THEREOF AS TNF ALPHA INHIBITORS | FUJIFILM TOYAMA CHEMICAL CO LTD (JP) | 2019-03-27 | — | — | EP | disclosed |