Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.76 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.76 |
| ▸ | RAF1 | P04049 | 4/20 | 0.63 |
| ▸ | BRAF | P15056 | 4/20 | 0.63 |
| ▸ | KRAS | P01116 | 3/20 | 0.63 |
| ▸ | KDR | P35968 | 3/20 | 0.63 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.63 |
| ▸ | BTK | Q06187 | 12/20 | 0.51 |
| ▸ | SRC | P12931 | 9/20 | 0.51 |
| ▸ | LYN | P07948 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ARAF | P10398 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15000252 | 0.94 | KIT (0.86) | KITPDGFRARAF1BRAFKRAS | |
| SCHEMBL15006335 | 0.92 | KIT (0.70) | KITPDGFRARAF1BRAFKRAS | |
| SCHEMBL15006336 | 0.92 | KIT (0.72) | KITPDGFRARAF1BRAFKRAS | |
| SCHEMBL20852376 | 0.92 | KIT (0.64) | KITPDGFRARAF1BRAFKRAS | |
| SCHEMBL29800429 | 0.92 | KIT (0.64) | KITPDGFRARAF1BRAFKRAS | |
| Hydrochloric Acid SCHEMBL21796167 | 0.91 | KIT (0.69) | KITPDGFRARAF1BRAFKRAS | |
| Hydrochloric Acid SCHEMBL21796184 | 0.91 | KIT (0.71) | KITPDGFRARAF1BRAFKRAS | |
| SCHEMBL14999838 | 0.91 | KIT (0.75) | KITPDGFRARAF1BRAFKRAS | |
| SCHEMBL17244719 | 0.89 | KIT (0.68) | KITPDGFRARAF1BRAFKRAS | |
| SCHEMBL15000009 | 0.88 | KIT (0.73) | KITPDGFRARAF1BRAFKRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019056990-A1 | 1,2-DIHYDRO-1,6-NAPHTHYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINE | 浙江海正药业股份有限公司 | 2019-03-28 | — | — | WO | disclosed |