Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 10/20 | 0.55 |
| ▸ | RAF1 | P04049 | 9/20 | 0.55 |
| ▸ | KRAS | P01116 | 6/20 | 0.55 |
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.55 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | BTK | Q06187 | 5/20 | 0.42 |
| ▸ | LYN | P07948 | 4/20 | 0.42 |
| ▸ | ARAF | P10398 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20852376 | 1.00 | KIT (0.64) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL20852395 | 0.94 | BRAF (0.64) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL29800826 | 0.94 | BRAF (0.64) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL20852503 | 0.92 | KIT (0.76) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL29800828 | 0.91 | KIT (0.64) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL20852384 | 0.91 | KIT (0.64) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL20852461 | 0.89 | KIT (0.51) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL20852397 | 0.86 | KIT (0.86) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL20852396 | 0.86 | KIT (0.71) | KITPDGFRABRAFRAF1KRAS | |
| SCHEMBL29800851 | 0.86 | KIT (0.86) | KITPDGFRABRAFRAF1KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111094286-B | 1, 2-dihydro-1, 6-naphthyridine derivatives, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2022-07-29 | — | — | CN | disclosed |