Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | GPR183 | P32249 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22282967 | 0.98 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL20855374 | 0.90 | GPR183 (0.59) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL20866521 | 0.87 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL14441230 | 0.85 | RAB9A (0.91) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL20866612 | 0.85 | NPC1 (0.48) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL20855414 | 0.84 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL20866598 | 0.83 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL3115258 | 0.82 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL3122017 | 0.82 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL3115263 | 0.82 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3687311-A1 | AMIDES FOR GENERATING A TRIGEMINAL EFFECT | Symrise AG (DE) | 2020-08-05 | — | — | EP | claimed |
| EP-3687311-A1 | AMIDES FOR GENERATING A TRIGEMINAL EFFECT | Symrise AG (DE) | 2020-08-05 | — | — | EP | disclosed |
| WO-2019063069-A1 | AMIDES FOR GENERATING A TRIGEMINAL EFFECT | SYMRISE AG (DE) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019063069-A1 | AMIDES FOR GENERATING A TRIGEMINAL EFFECT | SYMRISE AG (DE) | 2019-04-04 | — | — | WO | disclosed |