Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143912 | 1.00 | CYP2D6 (0.49) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| Hydrochloric Acid SCHEMBL20855876 | 0.98 | MEN1 (0.50) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| Hydrochloric Acid SCHEMBL3538526 | 0.98 | MEN1 (0.50) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL30178974 | 0.85 | KDM4E (0.41) | CYP2D6ADRA2AADRA1AKDM4ETDP1 | |
| SCHEMBL4974576 | 0.85 | KDM4E (0.41) | CYP2D6ADRA2AADRA1AKDM4ETDP1 | |
| SCHEMBL21673459 | 0.85 | KDM4E (0.41) | CYP2D6ADRA2AADRA1AKDM4ETDP1 | |
| SCHEMBL3917312 | 0.84 | LPAR1 (0.49) | CYP2D6KDM4ETDP1LMNA | |
| SCHEMBL27885171 | 0.82 | LMNA (0.42) | CYP2D6ADRA2AADRA1AMAPK1KDM4E | |
| SCHEMBL20855649 | 0.81 | TSHR (0.47) | MEN1MAPK1KMT2AKDM4ELMNA | |
| SCHEMBL20855651 | 0.81 | TSHR (0.47) | MEN1MAPK1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |