Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22113975 | 0.86 | MAPT (0.39) | CYP3A4CA9MAPK1MAPTHTT | |
| SCHEMBL7519389 | 0.85 | CA12 (0.55) | CA9MAPK1MAPTHTTRAB9A | |
| SCHEMBL31335892 | 0.84 | KMT2A (0.43) | CYP3A4CA9MAPK1MAPTHTT | |
| SCHEMBL20855913 | 0.81 | SMN1; SMN2 (0.48) | CYP3A4CA9MAPK1MAPTHTT | |
| SCHEMBL14416606 | 0.81 | ALDH1A1 (0.59) | CYP3A4CA9MAPK1MAPTHTT | |
| SCHEMBL9608358 | 0.80 | DPP4 (0.41) | CYP3A4MAPK1MAPTHTTRAB9A | |
| SCHEMBL24497063 | 0.80 | CA9 (0.58) | CYP3A4CA9MAPK1MAPTHTT | |
| SCHEMBL18857970 | 0.78 | CYP3A4 (0.47) | CYP3A4CA9MAPK1MAPTHTT | |
| SCHEMBL3767546 | 0.77 | TOP1 (0.40) | CYP3A4MAPTHTTLMNAKDM4E | |
| SCHEMBL3660100 | 0.76 | CYP3A4 (0.63) | CYP3A4CA9MAPK1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |