Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20855639 | 0.82 | KMT2A (0.39) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL20855788 | 0.77 | KDM4E (0.44) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL18013563 | 0.77 | KDM4E (0.49) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL22040677 | 0.77 | POLB (0.44) | KDM4EL3MBTL1CA9ALDH1A1LMNA | |
| SCHEMBL3120368 | 0.75 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL18013560 | 0.75 | ALDH1A1 (0.41) | KDM4EL3MBTL1CA9ALDH1A1LMNA | |
| SCHEMBL14354165 | 0.73 | PPARA (0.48) | KDM4EL3MBTL1MAPT | |
| SCHEMBL2486981 | 0.72 | KMT2A (0.45) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL13634487 | 0.72 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL28001264 | 0.72 | KDM4E (0.47) | PDE4BPDE4APDE4CPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |