Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | CTSC | P53634 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL5317118 | 0.92 | KMT2A (0.63) | KMT2AMEN1KDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL23924534 | 0.91 | KMT2A (0.70) | KMT2AMEN1KDM4EMAPTLMNA | |
| Tryptophan SCHEMBL3498464 | 0.89 | KDM4E (0.73) | KMT2AMEN1KDM4EMAPTLMNA | |
| Tryptophan SCHEMBL3495873 | 0.89 | KDM4E (0.73) | KMT2AMEN1KDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL21199671 | 0.88 | KMT2A (0.60) | KMT2AMEN1KDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL27480942 | 0.88 | KMT2A (0.68) | KMT2AMEN1KDM4EMAPTLMNA | |
| Tryptophan SCHEMBL4291975 | 0.88 | MEN1 (0.57) | KMT2AMEN1KDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL11461241 | 0.87 | KMT2A (0.76) | KMT2AMEN1KDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL23924440 | 0.87 | KMT2A (0.76) | KMT2AMEN1KDM4EMAPTLMNA | |
| Tryptophan SCHEMBL2229691 | 0.87 | KMT2A (0.76) | KMT2AMEN1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3688021-A1 | USE OF METFORMIN AND ANALOGS THEREOF TO REDUCE RAN PROTEIN LEVELS IN THE TREATMENT OF NEUROLOGICAL DISORDERS | University of Florida Research Foundation, Incorporated (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2019067587-A1 | USE OF METFORMIN AND ANALOGS THEREOF TO REDUCE RAN PROTEIN LEVELS IN THE TREATMENT OF NEUROLOGICAL DISORDERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-04-04 | — | — | WO | disclosed |