Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | CTSC | P53634 | 3/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL5317118 | 0.95 | KMT2A (0.63) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL5314267 | 0.92 | KDM4E (0.68) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL4290188 | 0.90 | KMT2A (0.53) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL293836 | 0.90 | MEN1 (0.49) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL3442743 | 0.89 | KMT2A (0.61) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL20857030 | 0.88 | KMT2A (0.57) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL27562096 | 0.87 | KMT2A (0.59) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL23924440 | 0.87 | KMT2A (0.76) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL2229691 | 0.87 | KMT2A (0.76) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL11461241 | 0.87 | KMT2A (0.76) | MEN1KMT2AKDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090220997-A1 | Stimulating G Protein-Coupled Receptors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2009-09-03 | — | — | US | disclosed |