Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 13/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167799 | 0.91 | SIRT2 (0.44) | SIRT2SIRT1SIRT3SIRT5SPHK1 | |
| SCHEMBL25100584 | 0.90 | SIRT2 (0.43) | SIRT2SIRT1SIRT3SIRT5SPHK1 | |
| SCHEMBL19443237 | 0.90 | SIRT2 (0.43) | SIRT2SIRT1SIRT3SIRT5SPHK1 | |
| SCHEMBL20327986 | 0.90 | SIRT2 (0.43) | SIRT2SIRT1SIRT3SIRT5SPHK1 | |
| SCHEMBL20880182 | 0.90 | SIRT2 (0.43) | SIRT2SIRT1SIRT3SIRT5F2 | |
| SCHEMBL27109512 | 0.89 | SIRT2 (0.45) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL21205411 | 0.89 | HSD17B10 (0.43) | SIRT2SIRT1SIRT3SIRT5PRSS1 | |
| SCHEMBL16791610 | 0.89 | ANPEP (0.48) | SIRT2SIRT1SIRT3SIRT5SPHK1 | |
| SCHEMBL29019194 | 0.88 | SIRT2 (0.46) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL21205432 | 0.88 | SIRT2 (0.48) | SIRT2SIRT1SIRT3SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054991-B1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS INC (US) | 2019-04-03 | — | — | EP | disclosed |