Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 6/20 | 0.47 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20865305 | 1.00 | KLK5 (0.53) | KLK5HDAC8ALDH1A1NPSR1ITGB3 | |
| SCHEMBL12835440 | 0.89 | ACE (0.58) | HDAC8ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL27278646 | 0.87 | KLK5 (0.54) | KLK5HDAC8ALDH1A1NPSR1ITGB3 | |
| SCHEMBL2729462 | 0.86 | KLK5 (0.51) | KLK5HDAC8ITGB3ITGA2BCTSS | |
| SCHEMBL22427549 | 0.86 | KLK5 (0.53) | KLK5HDAC8ALDH1A1NPSR1ITGB3 | |
| SCHEMBL27278632 | 0.86 | KLK5 (0.53) | KLK5HDAC8ALDH1A1NPSR1ITGB3 | |
| SCHEMBL12029082 | 0.85 | KLK5 (0.52) | KLK5HDAC8ALDH1A1NPSR1ITGB3 | |
| SCHEMBL15081043 | 0.85 | KLK5 (0.52) | KLK5HDAC8ALDH1A1NPSR1ITGB3 | |
| SCHEMBL6679774 | 0.84 | ITGB3 (0.51) | KLK5HDAC8ALDH1A1NPSR1ITGB3 | |
| SCHEMBL19234613 | 0.84 | KLK5 (0.59) | KLK5HDAC8ITGB3ITGA2BCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019067543-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-04-04 | — | — | WO | disclosed |