Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CFB | P00751 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | CTSA | P10619 | 2/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20869154 | 0.87 | AR (0.40) | SLC6A4ARPDE5ACTSATRPV4 | |
| SCHEMBL18923587 | 0.80 | AR (0.44) | SLC6A4ARCTSATRPV4KDM1A | |
| SCHEMBL20869152 | 0.79 | AR (0.35) | SLC6A4ARPDE5ACTSATRPV4 | |
| SCHEMBL20855647 | 0.79 | AR (0.43) | SLC6A4ARTRPV4KDM1AMEN1 | |
| SCHEMBL20855644 | 0.79 | AR (0.43) | SLC6A4ARTRPV4KDM1AMEN1 | |
| SCHEMBL20869209 | 0.77 | CYP2D6 (0.41) | SLC6A4CYP2D6CTSAKCNH2SLC6A3 | |
| SCHEMBL523615 | 0.76 | AR (0.49) | SLC6A4ARCYP2D6PDE5AKDM1A | |
| SCHEMBL17731548 | 0.74 | AR (0.47) | SLC6A4ARPDE5ACTSAKDM1A | |
| SCHEMBL17731549 | 0.74 | AR (0.47) | SLC6A4ARPDE5ACTSAKDM1A | |
| SCHEMBL24767631 | 0.74 | AR (0.40) | SLC6A4ARCTSATRPV4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |