Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31010990 | 0.78 | PDE4B (0.45) | PDE4BKDM4EPDE4APDE4CPDE4D | |
| SCHEMBL18606101 | 0.78 | PDE4B (0.45) | PDE4BKDM4EPDE4APDE4CPDE4D | |
| SCHEMBL30358862 | 0.78 | PDE4B (0.43) | PDE4BKDM4EPDE4APDE4CPDE4D | |
| SCHEMBL7917474 | 0.78 | PDE4B (0.43) | PDE4BKDM4EPDE4APDE4CPDE4D | |
| SCHEMBL12062521 | 0.78 | KDM4E (0.49) | KDM4EL3MBTL1TGFBR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25601599 | 0.78 | PDE4B (0.39) | PDE4BKDM4EPDE4APDE4CPDE4D | |
| SCHEMBL12538667 | 0.78 | TRPV3 (0.56) | HPGDLMNATP53HTTKMT2A | |
| SCHEMBL25791611 | 0.77 | PDE4B (0.43) | PDE4BKDM4EL3MBTL1PDE4APDE4C | |
| SCHEMBL23554835 | 0.76 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL29550138 | 0.76 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |
| CN-104254525-B | aromatic ring compound | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2016-05-25 | — | — | CN | disclosed |
| CN-104254525-A | Aromatic ring compound | TAKEDA PHARMACEUTICAL | 2014-12-31 | — | — | CN | disclosed |
| CN-101677569-B | 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof | EVOTEC AG | 2014-01-22 | — | — | CN | disclosed |
| CN-101677569-A | 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof | RENOVIS INC | 2010-03-24 | — | — | CN | disclosed |