Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 12/20 | 0.76 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.64 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.64 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.64 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109761 | 1.00 | TDP1 (0.76) | TDP1KARS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9107959 | 0.91 | TDP1 (0.78) | TDP1KARS1HDAC3HDAC1HDAC2 | |
| SCHEMBL11817724 | 0.88 | TDP1 (0.82) | TDP1KARS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9112314 | 0.88 | TDP1 (0.82) | TDP1KARS1HDAC3HDAC1HDAC2 | |
| SCHEMBL20856806 | 0.88 | TDP1 (0.82) | TDP1KARS1HDAC3HDAC1HDAC2 | |
| SCHEMBL29975241 | 0.87 | TDP1 (0.79) | TDP1KARS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9111830 | 0.84 | TDP1 (0.79) | TDP1KARS1HDAC3HDAC1HDAC2 | |
| SCHEMBL18431216 | 0.84 | MEN1 (0.74) | TDP1KARS1MEN1CYP3A4KMT2A | |
| SCHEMBL16204336 | 0.84 | MEN1 (0.74) | TDP1KARS1MEN1CYP3A4KMT2A | |
| SCHEMBL14447522 | 0.84 | TDP1 (0.78) | TDP1KARS1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611786-B2 | Manganese (III) catalyzed C—H aminations | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-04-07 | — | — | US | disclosed |
| US-20190106448-A1 | MANGANESE (III) CATALYZED C--H AMINATIONS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2019-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10611786-B2 | Manganese (III) catalyzed C—H aminations | HLCS, NCL, NUDC | TDP1 4124/4885KARS1 601/4885HDAC3 946/4885 |
| US-20190106448-A1 | MANGANESE (III) CATALYZED C--H AMINATIONS | HLCS, NCL, NUDC | TDP1 3977/4885KARS1 577/4885HDAC3 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.