Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.47 |
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | PTGES | O14684 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7110475 | 0.85 | HTR1A (0.53) | NPC1RAB9AKMT2AHTR1AADRA1D | |
| SCHEMBL7976948 | 0.84 | NPC1 (0.54) | NPC1SMN1; SMN2RAB9AKMT2AHTR1A | |
| SCHEMBL30153963 | 0.83 | CYP19A1 (0.47) | NPC1SMN1; SMN2RAB9AKMT2ACYP19A1 | |
| SCHEMBL30449234 | 0.82 | CYP19A1 (0.51) | NPC1SMN1; SMN2RAB9AKMT2AHTR1A | |
| SCHEMBL3873841 | 0.82 | CYP19A1 (0.51) | NPC1SMN1; SMN2RAB9AKMT2AHTR1A | |
| SCHEMBL2420234 | 0.81 | NPC1 (0.53) | NPC1SMN1; SMN2RAB9AKMT2AHTR1A | |
| SCHEMBL4947178 | 0.81 | SMN1; SMN2 (0.51) | NPC1SMN1; SMN2RAB9AKMT2AHTR1A | |
| SCHEMBL4946688 | 0.80 | SMN1; SMN2 (0.50) | NPC1SMN1; SMN2RAB9AKMT2AHTR1A | |
| SCHEMBL11693495 | 0.78 | TDP1 (0.67) | NPC1SMN1; SMN2RAB9AKMT2ACYP19A1 | |
| SCHEMBL14339705 | 0.77 | NPC1 (0.47) | NPC1SMN1; SMN2RAB9AKMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111417630-B | Modulators of interferon gene stimulating factor (STING) | 葛兰素史克知识产权开发有限公司 | 2023-06-06 | — | — | CN | disclosed |
| US-11377440-B2 | Modulators of stimulator of interferon genes (STING) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-07-05 | — | — | US | disclosed |
| US-20200291001-A1 | MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-09-17 | — | — | US | disclosed |
| EP-3692034-A1 | MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-08-12 | — | — | EP | disclosed |
| CN-111417630-A | Modulators of interferon gene stimulating factor (STING) | 葛兰素史克知识产权开发有限公司 | 2020-07-14 | — | — | CN | disclosed |
| WO-2019069270-A1 | MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-11 | — | — | WO | disclosed |
| WO-2019069270-A1 | MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11377440-B2 | Modulators of stimulator of interferon genes (STING) | STING1, IRF3, IFNAR1 | NPC1 4463/4885SMN1; SMN2 2468/4885RAB9A 678/4885 |
| US-20200291001-A1 | MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) | STING1, IRF3, IFNAR1 | NPC1 4463/4885SMN1; SMN2 2468/4885RAB9A 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.